The reference site for Bromhexine

Bromhexine is a mucolytic (expectorant) agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.

WHAT IS BROMHEXINE?

Bromhexine is a mucolytic agent used in the treatment of respiratory disorders (eg. cough with phlegm) associated with viscid or excessive mucus.

Bromhexine supports the body’s own natural mechanisms for clearing mucus from the respiratory tract.

This medication is secretolytic, which means that it increases the production of serous mucus in the respiratory tract and makes the phlegm thinner and less sticky. This contributes to a secretomotoric effect: it helps the cilia – tiny hairs that line the respiratory tract – to transport the phlegm out of the lungs. For this reasons it is often added to some antitussive (cough) syrups.

Bromhexine is sold worldwide under the brand name Bisolvon® by Boehringer Ingelheim, as well as under other trade names.

 

Brand Name(s): Bisolvon; Barkacin
CAS nº: 611-75-6
(brom-hex-een)

 

Product Info

The sections below will provide you with more specific information and guidelines related to bromhexine and its correct use. Please read them carefully.

FDA Information

Bromhexine was discovered following investigation in the Asian plant Adhatoda vasica. This plant is well known in the traditional Ayurvedic medicine of India for its secretolytic action. Its dried leaves were administered as a tea against cough and asthma. The active ingredients of this plant were found to be adhatodic acid and vasicine, an alkaloid compound. Bromhexine was obtained as the synthetic derivative of vasicine.

Bromhexine was shown to have outstanding expectorant properties. It was more effective than vasicine in stimulating secretion of fluid by the mucous glands of the respiratory tract, thereby improving its clearance function. Bromhexine was developed in the research laboratories of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use.

Introduced in 1963 under the trademark Bisolvon®, bromhexine has since been appreciated as a reliable and safe secretolytic expectorant for the effective treatment of cough with phlegm.

Additionally, Bisolvon® has become one of the world’s most trusted treatments for productive cough.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Bromhexine is a mucolytic agent used in the treatment of respiratory disorders (eg. cough with phlegm) associated with viscid or excessive mucus.

Bromhexine supports the body’s own natural mechanisms for clearing mucus from the respiratory tract.

This medication is a secretolytic, which means that it increases the production of serous mucus in the respiratory tract and makes the phlegm thinner and less sticky. This contributes to a secretomotoric effect: it helps the cilia – tiny hairs that line the respiratory tract – to transport the phlegm out of the lungs. For this reasons it is often added to some antitussive (cough) syrups.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Note: Bisolvon® (bromhexine) may also be used to treat respiratory disease in animals.

Dosage and using this medicine

Bromhexine is available as syrup, drops and tablets in various pack sizes and dosages for children and adults.

The most recent product launch is a syrup that taste of strawberry. It is meant especially for children and can be taken from 2 years and upwards.

The recommended doses for adults and children are stated below:

Adult and children over 12 years: 1 tablet 3 times daily.
– Children 6-12 years: ½ tablet 3 times daily.
– Children 2-6 years: ¼ tablet 2 times daily.

Bromhexine is not recommended for children under 2 years of age without medical advice.

Please be aware that over-the-counter remedies such as Bisolvon® are recommended to be taken for about one week in the case of adults and older children who are normally in healthy condition.

What special precautions should I follow?

BEFORE TAKING BROMHEXINE:

Do not use bromhexine if you are allergic to this medication or to any of the other ingredients in Bisolvon®, for example. If you are not sure if you have these allergies, you should raise those concerns with your doctor or pharmacist.

Tell your doctor or pharmacist if you have, or have had, any of the following conditions: liver problems, kidney problems, or stomach ulcers. If you are not sure if you have, or have had, any of these conditions, you should raise those concerns with your doctor or pharmacist.

Tell your doctor or pharmacist if you are taking any other medicines, obtained with or without a doctor’s prescription. Bromhexine may increase the amount of antibiotic penetration.

Ask for your doctor’s advice if you are pregnant, or likely to become pregnant during your course of medication. Special care is recommended during pregnancy. The benefits of bromhexine medications must be assessed against possible effects on your child.

Ask for your doctor’s advice if you are breastfeeding, or likely to breastfeed during your course of medication. This medication is expected to pass into breast milk, therefore it is not recommended that bromhexine be taken by women who are breastfeeding.

What should I do if I forget a dose?

Take the medicine as soon as you remember. However, if it is close to the time to take the next dose, skip one dose and return to the usual schedule of medication from the next dose.

It is strongly advised never to take two doses at a time.

What side effects can this medication cause?

You should be aware that all medicines carry some risks and that all possible risks may not be known at this stage despite thorough testing. Ask for the advice of your doctor or pharmacist if you have any concerns about the effects of taking bromhexine.

Occasional, mild side effects from this medication may include:

nausea
diarrhoea
indigestion
a feeling of fullness in the stomach (a bloated feeling)

Very rarely, serious allergic reactions have occurred with the use of bromhexine. Symptoms of allergic reactions may include:

skin rashes
difficulty in breathing
swelling of the face, lips, mouth, tongue or throat which may cause difficulty swallowing or breathing

Tell your doctor or pharmacist as soon as possible if you experience any side effects during or after taking bromhexine, so that these may be properly treated.

In addition, unexpected effects, not listed above, can occur with any medicine. You should tell your doctor or pharmacist if you notice anything unusual, during or after taking this medication.

When you take bromhexine, you may notice an increase in mucus from your air passages. This is common when taking this medication as this is characteristic of how bromhexine works.

What storage conditions are needed for this medicine?

Bromhexine should be kept in a cool dry place where the temperature stays below 30°C.

Please remember to throw away any medication that is outdated or no longer needed. If you have any questions, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

Seek medical advice if you have taken more than the recommended or prescribed dose of bromhexine. Advice can be provided by your local doctor or pharmacist.

Product Images

PICTURES OF BROMHEXINE PRODUCTS

Below you will find images and specific information on the principal types of bromhexine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.
The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: BISOLVON®
Strength(s): 8 MG / 8 ML
Imprint: BISOLVON ELIXIR
Manufacturer: BOEHRINGER INGELHEIM

Name: BARKACIN®
Strength(s): 8 MG
Imprint: BARKACIN
Manufacturer: BARAKAT PHARMACEUTICALS

Name: BROMHEXINE
Strength(s): 8 MG
Imprint: BROMHEXINE
Manufacturer: TAIZHOU WANBANG

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